Comparative Evaluation of the Effects of Atorvastatin and Lovastatin on the Pharmacokinetics of Aliskiren in Rats

The worldwide increase in the number patients with high blood pressure poses serious clinical challenges. Little is known regarding interactions between various drugs used to treat heart diseases. present study evaluates and compares effects of administration multiple doses atorvastatin or lovastatin on pharmacokinetics aliskiren rats an effort determine their underlying mechanisms. A total 90 healthy female albino were randomly divided into three groups. All groups treated by oral gavage at 8.57 mg/kg daily for 14 days. In addition aliskiren, group 2 received a dose 1.143 7 3 After samples collected specific time intervals, concentrations determined using liquid chromatography-tandem mass spectrometry. Relative control treatment, treatment resulted non-significant alterations pharmacokinetic parameters aliskiren. contrast, significant area under curve, peak plasma concentration, elimination half-life 21, 10, 72%, respectively. Additionally, significantly reduced clearance 23%. Inhibition metabolism via hepatic CYP3A subfamily and/or inhibition intestinal P-glycoprotein was identified as possible mechanism. This first report that only causes marked bioavailability. Caution should be taken when are administrated concomitantly practice.